Defining differential markers for symptomatic and asymptomatic Brachyspira hyodysenteriae isolates
Research partner: Moredun Research Institute
Sponsor: AHDB Pork
Duration: 2009 – 2012
Aims and objectives
- To identify substantial differences between virulent and presumably avirulent B. hyodysenteriae isolates
- To develop approaches that can subsequently be used towards disease control through a potential differential test or vaccination.
Findings to date
- The project has contributed to the understanding of how B. hyodysenteriae colonises hosts and causes disease
- The research has provided knowledge in the response of B. hyodysenteriae under stress eg iron-starvation, which has not been reported before
- The proteins catalogued could be an important resource for the comparison of future proteomics studies in B. hyodysenteriae
- The identification of these proteins offers new starting points for research areas including the investigation of predicted lipoproteins, which might have an important function in pathogenesis and could be therefore contribute to the control of, and perhaps even eradication of, SD from the UK and elsewhere.