The infection biology of pig-associated Salmonella
Research partners: Liverpool University
Sponsors: AHDB Pork-funded studentship (Georgina Crayford)
Duration: 2010 –2014
Aims and objectives
To infect pig intestinal epithelial cells with different strains of serovars and to characterise:
- The behaviour of Salmonella
- The immunological response of the epithelial cells upon invasion of the bacteria
- Any differences that might exist between the strains.
The overall objective was to add to the current limited knowledge of the pathogenicity of monophasic S. Typhimurium DT193 isolates and determine the reasons behind their rapid and worldwide spread in recent years.
This work is in line with the UK Food Standards Agency (FSA) strategic plan to reduce the numbers of pigs testing positive for Salmonella at slaughter.
- It is necessary to maintain awareness of the presence of epidemic strains and improve surveillance
- This study has gone some way towards contributing to the understanding the host-pathogen interaction
- It has shown that monophasic isolates of Salmonella present in British pig herds possess a range of virulence characteristics
- Attempts to limit their spread and prevent their entry into products destined for human consumption should be made, particularly since they carry antimicrobial resistance.
- Georgina has been named as a co-author on a publication in Avian Pathology and in October 2013 findings from the research were presented at the prestigious American Society of Microbiology Salmonella conference.
- Project presentation
- PhD seminar presentation (2013
- Project Summary
- Project Review Document
- Find out more about PhD student Georgina Crayford here